Pentobarbital boosts toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Watch Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases threat of adverse reactions like overdose, respiratory despair, and Demise. Cessation of benzodiazepines or other CNS depressants is desired normally. pentobarbital wi... https://joanr396gwk3.wikigiogio.com/user