Abstract Multi-injection pharmaceutical merchandise such as insulin has to be formulated to prevent aggregation and microbial contamination. Tiny-molecule preservatives and nonionic surfactants including poloxamer 188 (P188) are thus generally employed in protein drug formulations. Nonetheless, mixtures of preservatives and surfactants can induce aggregation and in some cases phase se... https://polo-18843310.daneblogger.com/32566790/polo-188-fundamentals-explained