It is usually important to acquire into consideration that polymorphism both in CB1 and CB2 is likely to be answerable for toxicity related to utilization of SCBs. One nucleotide polymorphism in the two receptors (references), together with incidence of CB1 variants was described from the literature. The next references are https://jaidenjpqrq.thezenweb.com/the-smart-trick-of-jwh-018-alternative-that-nobody-is-discussing-65002388