Product 21C (a 220gr. Challenging Solid basic based LFN) is absolutely the heaviest bullet that can be fired via 10MM pistols. With its flat nose, it will penetrate straight and very deeply into muscle and bone. Straight line penetration into living tissue will exceed a few feet. Having said that, https://buffaloammunition.wixsite.com/buffaloammunition/post/top-5-accessories-for-enhancing-your-buffalo-bore-experience